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Managing the Course of Kidney Disease in Adults With Type 2 Diabetes: From the Old to the New.

LMC Diabetes & Endocrinology, Thornhill, Ontario, Canada. Electronic address: ronaldgoldenberg@gmail.com. Vaughan Heart Institute, Humber River Hospital, Toronto, Ontario, Canada. Division of Nephrology, University Health Network, Toronto, Ontario, Canada; Department of Physiology, University of Toronto, Toronto, Ontario, Canada. Division of Endocrinology & Metabolism, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada. Division of Nephrology, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada. University of Alberta, Edmonton, Alberta, Canada. Division of Cardiac Surgery, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.

Canadian journal of diabetes. 2018;(3):325-334
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Abstract

Diabetic kidney disease (DKD) is a group of chronic kidney diseases that is associated with significant cardiovascular as well as all-cause morbidity and mortality. Although DKD is often progressive in nature, its evolution can be modified by intensive management of glycemia and blood pressure and inhibition of the renin-angiotensin-aldosterone system. This review provides an overview of how multifactorial interventions can provide renal protection and includes a discussion of the nonglycemic effects of incretin-based diabetes therapies (glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase 4 inhibitors) and sodium-glucose cotransporter-2 inhibitors within the kidney in patients with type 2 diabetes.

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Publication Type : Case Reports ; Review

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